Welcome to the Department of Biology

Department of Biology at Illinois State University
Department of Biology

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Dr. Craig Gatto

School Director
Professor
  • CURRENT COURSES
  • BSC 499.Sec 004 Independent Research For The Masters Thesis
  • RESEARCH INTERESTS
  • The active transport of ions across cell membranes is performed by P-type ATPases. These are integral membrane proteins which use the energy of hydrolysis of ATP to pump ions across biological membranes. The mechanism by which these proteins couple ATP hydrolysis to ion transport is one of the central interests of the laboratory. My laboratory focuses on structure-function studies, molecular mechanism, assembly and subcellular trafficking of these important transporters. P-type pumps are tansiently phosphorylated from ATP and transport alkali metals (e.g. Na+, K+, H+, Ca2+) as well as heavy metals (e.g Cu2+ and Cd2+). Members of this protein superfamily are represented across all phyla.
  • Ph D Physiology - 1993
  • University of Missouri-Columbia
  • Columbia MO
  • Dissertation/Thesis topic: Fluorescein Analogue Inhibition of the Erythrocyte Ca2+ Pump
  • MS Zoology / Chemistry - 1989
  • Eastern Illinois University
  • Charleston, IL
  • Dissertation/Thesis topic: “Effects of Methylxanthines on Newborn Rat Respiration”.
  • BS Zoology - 1987
  • Eastern Illinois University
  • Charleston, IL
  • SELECTED PUBLICATIONS
  • Jeff B. Helms, Jamie Meyer, Charles J. Costa, Eric Plowman, Jeremy P. Holden, Nick Williford, Matthew Corbitt, Craig Gatto. Inhibition of the Na,K-ATPase by the acetaminophen metabolite N-acetylbenzoquinoneimine. J. Integrative & Mol. Physiol. 5, 1-17, 2015.
  • Dale MD, Mortimer EM, Kolli S, Achramowicz E, Borchert G, Juliano SA, Halkyard S, Sietz N, Gatto C, Hester PY and Rubin DA. 2015. Bone-remodeling transcript levels are independent of perching in end-of-lay white leghorn chickens. Int. J. Mol. Sci. 16:2663-2677.
  • Travis J. Mitchell, Camila Zugarramurdi, J. Fernando Olivera, Craig Gatto and Pablo Artigas. Sodium and Proton Effects on Inward Proton Transport Through Na/K pumps. Biophysical Journal. 106, 2555-2565, 2014.
  • Peter D. Ziniel, Janish Desai, Cynthia L. Cass, Craig Gatto, Eric Oldfield, David L. Williams. Characterization of farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni: potential drug targets. Antimicrobial Agents and Chemotherapy. 57, 5969-5976, 2013.
  • Charitha Galva, Gail Virgin, Jeff Helms and Craig Gatto. ATP protects against FITC labeling of Solanum lycopersicon and Arabidopsis thaliana Ca-ATPase ATP binding domains. Plant Physiology & Biochemistry. 71, 261-267, 2013.
  • Charitha Galva, Pablo Artigas, Craig Gatto. Nuclear Na,K-ATPase plays a role in Nucleoplasmic Calcium Homeostasis. J. Cell Science. 125 (24), 6137-6146, 2012.
  • Borchert, G. Holton, N. Williams, J. Bishop, I. Dembosky, J. Elste, J. Gregoire, N. Hernan, W. Kim, J. Koehler, W. Lengerich, J. Medema, A. Nguyen, M. Ower, G. Rarick, M. Strong, B. Tardi, N. Tasker, N. Wozniak, D. Gatto, C. Larson, E. (2011). Comprehensive Analysis of MicroRNA Genomic Loci Identifies Pervasive Repetitive-Element Orgins, Mob. Gen. Elements . Vol. 1 ( 1 )

  • Ratheal, I.M., Virgin, G.K., Yu, H., Roux, B., Gatto, C., and Artigas, P. Selectivity of externally facing ion-binding sites in the Na/K pump to alkali metals and organic cations. Proc. Natl. Acad. Sci. USA. 107, 18718–18723, 2010.
  • Gatto, Craig. NO control: nitric oxide directly regulates substrate delivery to NOS. Am. J. Physiol. – Cell Physiol. 299, C213 – C215, 2010.
  • Johnson, N.A., Liu, F., Weeks, P.D., Hentzen, A.E., Kruse, H.P., Parker, J.J., Laursen, M., Nissen, P., Costa, C.J., and Gatto, C. A Tomato ER-type Ca2+-ATPase, LCA1, has a Low Thapsigargin-sensitivity and can Transport Manganese. Arch. Biochem. & Biophysics. 481, 157-168, 2009.
  • Yaragatupalli, S., Olivera, J.F., Gatto, C., and Artigas, P. Altered Sodium transport after an intracellular alpha-subunit deletion reveals strict external sequential release of sodium ions from the Na/K pump. Proc. Natl. Acad. Sci. USA. 106, 15507-15512, 2009.
  • PRESENTATIONS
  • FUNDED GRANTS
  • NIH R15 - Academic Research Enhancement Award. "Cell Physiology of Na,K-ATPase". 7/01/2015 - 06/30/2018.
  • NIH R15 "Branched-chain fatty acids and membrane function in Listeria monocytogenes." 9/1/2012 - 8/31/2016. Co-Investigator (PI: Dr. Brian J. Wilkinson)
  • Outstanding University Researcher Award
  • Illinois State University
  • 2009
  • Faculty Star
  • ISU Men's Basketball game
  • 2009
  • 2008 Class of Outstanding Graduate Alumni
  • Eastern Illinois University Graduate School
  • 2008
  • Outstanding College Researcher Award
  • Illinois State University
  • 2008
  • Outstanding College Service Award
  • College of Arts and Sciences
  • 2007
  • University Research Initiative Award
  • Illinois State University
  • 2001
  • James Metcalfe Outstanding Reserach Proposal
  • American Heart Association
  • 1996
  • James Metcalfe Outstanding Reserach Proposal
  • American Heart Association
  • 1995
  • Student Reseracher Award
  • University of Missouri-Columbia
  • 1993
  • Outstanding Gradaute Researcher Award
  • Eastern Illinois University
  • 1989