Paramyxoviruses

4/1/13

-RNA viruses

Helical capsid and envelope

Binding with glycoprotein (HN, H or G)

F protein facilitates fusion of envelope with host cell

Genome-

RNA associated with 3 proteins

NP-nucloprotein-structure-associates with matrix

L-large RNA polymerase

P-polymerase phosphoprotein-aids polymerase

Replication-

Transcription to full length genome and mRNA size fragments

Translation

Matrix protein and glycoproteins go to ER and are expressed on cell surface

RNA Negative strand synthesis

Rapidly associates with NP, P and L

Released by budding

x

Members-

Measles-cause cell fusion and Giant cells

Diagnosed by 3 Cs in early infection Cough, coryza, conjunctivitis

Koplik's spots

Fever is most severe component

May lead to encephalitis or subacute sclerosing panencephalitis

Parainfluenza-

Cold like but causes lower respiratory infections

Croup

Mumps-

Parotitis-saliva glands infected

Viremia-spreads to gonads

RSV-Respiratory syncytial virus